Regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA7A, ITGA3, and SRPX2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to wounding activity versus SEMA7A in LUNG_NSCLC_LUSC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SEMA7A →	+3.345	+0.131	<.001	<.001	3	14
BONE	ITGA3 →	+3.895	+0.121	<.001	<.001	3	14
SOFT_TISSUE	SRPX2 →	+3.388	+0.108	<.001	<.001	3	13
LARGE_INTESTINE	PMEPA1 →	+2.351	+0.092	.001	<.001	3	13
BONE	THBS1 →	+5.542	+0.130	<.001	<.001	3	13
BONE	FOSL1 →	+3.820	+0.115	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903034 vs SEMA7A — LUNG_NSCLC_LUSC

Explore this scatter interactively →