Regulation of response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAB1, TMEM42, and TSPO, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to wounding activity versus GAB1 in BLOOD_Lymphoma (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GAB1 →	-2.824	-0.189	<.001	<.001	3	5
BLOOD_Leukemia	TMEM42 →	+1.162	+0.235	<.001	<.001	3	5
PANCREAS	TSPO →	+1.011	+0.254	<.001	<.001	3	5
LUNG_SCLC	CTU1 →	+0.737	+0.263	.005	<.001	3	4
LUNG_SCLC	TMSB10 →	+1.436	+0.151	.001	.008	3	4
STOMACH	QPRT →	-4.971	-0.207	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903034 vs GAB1 — BLOOD_Lymphoma

Explore this scatter interactively →