Positive regulation of opsonization

Across TCGA cell cohorts, RNA activity of the Positive regulation of opsonization pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNPEP, TRIM52, and LSM6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNPEP grouped by Positive regulation of opsonization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DNPEP →	-0.167	-1.380	.002	.003	3	3
SOFT_TISSUE	TRIM52 →	+0.188	+1.435	.005	.002	3	3
BONE	LSM6 →	-0.596	-1.804	.001	<.001	3	3
LUNG_NSCLC_LUAD	TSPAN6 →	-0.143	-0.551	.005	.005	3	3
LUNG_SCLC	RIPPLY3 →	+0.242	+1.281	.003	.004	3	3
LUNG_SCLC	MIA-RAB4B →	-0.091	-0.929	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNPEP by Positive regulation of opsonization activity — SOFT_TISSUE

Explore this box plot interactively →