Positive regulation of opsonization

Across TCGA cell cohorts, RNA activity of the Positive regulation of opsonization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP3, ACY3, and PIK3CD, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of opsonization activity versus CASP3 in BLOOD_Lymphoma (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CASP3 →	+1.080	+1.406	.002	.002	3	2
BLOOD_Leukemia	ACY3 →	+2.420	+1.806	<.001	<.001	3	2
BLOOD_Leukemia	PIK3CD →	+2.033	+1.972	<.001	.001	3	2
BLOOD_Leukemia	RHOG →	-1.190	-1.841	.009	<.001	3	2
BREAST	GRAP2 →	+0.963	+1.570	.002	<.001	3	1
BREAST	AADAT →	+3.043	+1.503	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903028 vs CASP3 — BLOOD_Lymphoma

Explore this scatter interactively →