Regulation of opsonization

Across TCGA patient cohorts, RNA activity of the Regulation of opsonization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CGNL1, RPL12_S38, and FCSK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of opsonization activity versus CGNL1 in LSCC (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CGNL1 →	+0.293	+0.072	<.001	<.001	3	6
LUAD	RPL12_S38 →	-0.780	-0.061	.002	.009	3	5
CCRCC	FCSK →	+0.258	+0.076	<.001	<.001	3	5
CCRCC	ORC2_T226 →	-0.938	-0.127	<.001	<.001	3	5
BRCA	ADD3 →	+0.389	+0.039	.002	.001	3	5
BRCA	KBTBD11 →	+0.257	+0.025	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903027 vs CGNL1 — LSCC

Explore this scatter interactively →