Regulation of opsonization

Across TCGA patient cohorts, RNA activity of the Regulation of opsonization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD300E, MEDAG, and SRGN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of opsonization activity versus CD300E in COAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD300E →	+1.383	+0.339	<.001	<.001	3	6
GBM	MEDAG →	+1.064	+0.194	<.001	<.001	3	5
GBM	SRGN →	+0.840	+0.168	.003	<.001	3	5
GBM	CD93 →	+0.495	+0.110	.003	.007	3	5
UCEC	ADGRE3 →	+0.623	+0.253	<.001	<.001	3	5
GBM	C5AR2 →	+0.519	+0.186	.009	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903027 vs CD300E — COAD

Explore this scatter interactively →