Regulation of opsonization

Across TCGA cell cohorts, RNA activity of the Regulation of opsonization pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF15, EIF3J, and PCSK6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDF15 grouped by Regulation of opsonization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GDF15 →	-2.845	-0.461	.001	.003	3	5
STOMACH	EIF3J →	+0.751	+0.296	.004	.004	3	3
LUNG_NSCLC_LUSC	PCSK6 →	-3.108	-0.415	<.001	.001	3	3
LUNG_NSCLC_LUSC	TMF1 →	+0.825	+0.327	.003	.003	3	3
BLOOD_Myeloma	MYDGF →	-1.241	-1.245	.002	.004	3	3
BLOOD_Myeloma	IFIT5 →	-1.096	-1.279	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDF15 by Regulation of opsonization activity — SKIN

Explore this box plot interactively →