Regulation of opsonization

Across TCGA cell cohorts, RNA activity of the Regulation of opsonization pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFDC3, ARHGEF2, and UBXN2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WFDC3 grouped by Regulation of opsonization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WFDC3 →	+0.206	+0.245	.001	.006	3	4
LUNG_SCLC	ARHGEF2 →	-0.250	-1.036	.002	.001	3	3
LUNG_SCLC	UBXN2A →	+0.172	+1.483	.005	<.001	3	3
LIVER	CEP126 →	+0.370	+0.509	.001	.002	2	4
BLOOD_Leukemia	LRWD1 →	+0.662	+0.282	.001	.002	3	3
BLOOD_Leukemia	MAP3K11 →	+0.153	+0.156	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WFDC3 by Regulation of opsonization activity — OVARY

Explore this box plot interactively →