Negative regulation of glycoprotein metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIN3, AQP9, and GOLGA2P5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycoprotein metabolic process activity versus RIN3 in PDAC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RIN3 →	+0.285	+0.186	<.001	<.001	3	4
UCEC	AQP9 →	+0.907	+0.144	<.001	.002	3	4
UCEC	GOLGA2P5 →	-0.609	-0.125	.001	.009	3	4
LUAD	SEMA6B →	+0.455	+0.154	.003	.002	3	3
LUAD	TREML4 →	+0.430	+0.156	.001	<.001	3	3
BRCA	RPS26P6 →	+0.770	+0.200	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903019 vs RIN3 — PDAC

Explore this scatter interactively →