Negative regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMIZ2, ATG101, and N4BP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMIZ2 grouped by Negative regulation of glycoprotein metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZMIZ2 →	+0.827	+0.935	.002	.002	3	4
BONE	ATG101 →	-0.384	-1.782	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	N4BP1 →	+0.986	+1.701	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	RNF149 →	+1.163	+1.252	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	ZBTB43 →	+0.875	+1.725	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	HSBP1L1 →	+1.315	+1.530	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMIZ2 by Negative regulation of glycoprotein metabolic process activity — LUNG_SCLC

Explore this box plot interactively →