Negative regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HBEGF, JUP, and CDCA7, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycoprotein metabolic process activity versus HBEGF in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HBEGF →	+1.996	+0.137	.003	.003	3	10
LUNG_NSCLC_LUAD	JUP →	+1.970	+0.116	<.001	<.001	3	8
BLOOD_Lymphoma	CDCA7 →	-1.793	-0.108	<.001	<.001	3	8
SOFT_TISSUE	SDC4 →	+2.436	+0.105	.004	.003	3	8
SOFT_TISSUE	PIGT →	+0.681	+0.101	<.001	<.001	3	8
LARGE_INTESTINE	DOCK9 →	+1.219	+0.066	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903019 vs HBEGF — PANCREAS

Explore this scatter interactively →