Negative regulation of glycoprotein metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of glycoprotein metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAREM2, POLR1E, and EIF3L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of glycoprotein metabolic process activity versus GAREM2 in LUNG_NSCLC_LUAD (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GAREM2 →	-0.858	-0.903	.001	<.001	3	6
STOMACH	POLR1E →	-1.433	-1.465	.001	<.001	3	5
LARGE_INTESTINE	EIF3L →	-0.528	-0.864	.003	<.001	3	4
LARGE_INTESTINE	ENO2 →	-1.745	-1.008	<.001	<.001	3	4
LUNG_SCLC	TM9SF2 →	+0.821	+1.030	.003	<.001	3	4
BLOOD_Lymphoma	ATP10D →	-1.002	-0.890	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903019 vs GAREM2 — LUNG_NSCLC_LUAD

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