Organelle disassembly

Across TCGA patient cohorts, RNA activity of the Organelle disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, SEPTIN4_S432, and RPL26, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle disassembly activity versus RPL5 in BRCA (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL5 →	-0.173	-0.017	<.001	.001	3	7
BRCA	SEPTIN4_S432 →	+0.568	+0.024	.001	.006	3	6
LUAD	RPL26 →	-0.466	-0.029	.005	<.001	3	5
OV	CACNA2D1 →	+0.349	+0.030	.006	.003	3	5
PDAC	JPT1 →	-0.369	-0.026	<.001	.001	3	5
BRCA	NUP50 →	-0.304	-0.031	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903008 vs RPL5 — BRCA

Explore this scatter interactively →