Organelle disassembly

Across TCGA patient cohorts, RNA activity of the Organelle disassembly pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA10, TCP1, and USP9X, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle disassembly activity versus NAA10 in COAD (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NAA10 →	+0.385	+0.144	.008	.002	3	2
COAD	TCP1 →	+0.308	+0.120	<.001	<.001	3	2
COAD	USP9X →	+0.498	+0.126	.001	.001	3	2
COAD	MFAP1P1 →	+0.160	+0.124	<.001	.002	3	2
OV	XDH →	+1.649	+0.199	.008	.003	3	1
COAD	CDK16 →	+0.523	+0.140	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903008 vs NAA10 — COAD

Explore this scatter interactively →