Organelle disassembly

Across TCGA cell cohorts, RNA activity of the Organelle disassembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP188, SNX4, and SNRNP27, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Organelle disassembly activity versus NUP188 in LIVER (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NUP188 →	+0.825	+0.176	.006	.009	2	6
BLOOD_Myeloma	SNX4 →	+0.874	+0.191	.003	.006	3	5
UPPER_AERODIGESTIVE_TRACT	SNRNP27 →	+0.837	+0.222	.003	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	DENR →	+1.212	+0.257	.002	.008	2	6
CNS	SSB →	+0.481	+0.176	.003	.008	3	5
LARGE_INTESTINE	FAM204A →	+0.430	+0.099	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903008 vs NUP188 — LIVER

Explore this scatter interactively →