Positive regulation of protein deubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein deubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCN2, SNTB2_S222, and SKAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein deubiquitination activity versus LCN2 in GBM (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LCN2 →	+1.644	+0.073	<.001	<.001	3	7
BRCA	SNTB2_S222 →	+0.798	+0.070	<.001	<.001	3	7
OV	SKAP2 →	+0.547	+0.062	.002	.004	2	7
UCEC	CAST →	+0.324	+0.087	.002	.005	3	6
LUAD	TNKS1BP1_S920 →	+0.534	+0.051	.008	.002	3	6
BRCA	CARD9 →	+0.382	+0.080	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903003 vs LCN2 — GBM

Explore this scatter interactively →