Positive regulation of protein deubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL15, PRDX3, and CCDC144A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL15 grouped by Positive regulation of protein deubiquitination-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KLHL15 →	-1.087	-0.201	.002	<.001	3	4
BLOOD_Lymphoma	PRDX3 →	-0.873	-0.249	.008	.001	3	4
BLOOD_Myeloma	CCDC144A →	+2.298	+0.157	<.001	.003	3	4
SOFT_TISSUE	IQANK1 →	+0.847	+0.160	.001	.002	3	4
BREAST	HIC2 →	+0.682	+0.097	.003	.002	3	4
OVARY	ATP1B2 →	-0.554	-0.081	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL15 by Positive regulation of protein deubiquitination activity — URINARY_TRACT

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