Positive regulation of protein deubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LHX6, TSPAN3, and RPL18A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein deubiquitination activity versus LHX6 in BLOOD_Leukemia (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LHX6 →	+1.539	+0.144	<.001	.003	3	4
LUNG_SCLC	TSPAN3 →	-0.940	-0.204	.005	.008	3	4
CNS	RPL18A →	+1.080	+0.359	.006	<.001	3	4
CNS	TMEM248 →	-0.774	-0.272	.001	<.001	3	4
BLOOD_Lymphoma	MBIP →	-0.536	-0.108	.006	.008	3	4
BLOOD_Lymphoma	AGL →	-0.631	-0.115	.008	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903003 vs LHX6 — BLOOD_Leukemia

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