Positive regulation of amyloid precursor protein catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS23P2, SHC1P2, and IL1RL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid precursor protein catabolic process activity versus RPS23P2 in GBM (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS23P2 →	-0.171	-0.441	<.001	.004	3	3
LUAD	SHC1P2 →	+0.421	+0.120	.001	.005	3	3
BRCA	IL1RL1 →	+0.653	+0.324	<.001	<.001	3	3
BRCA	DIRC1 →	+0.380	+0.271	.003	.001	3	3
CCRCC	SLC25A38 →	-0.252	-0.386	.004	.002	2	3
BRCA	ARPC2 →	+0.336	+0.302	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902993 vs RPS23P2 — GBM

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