Positive regulation of amyloid precursor protein catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of amyloid precursor protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIF, MRPS2, and STX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of amyloid precursor protein catabolic process activity versus PPIF in LUNG_NSCLC_LUAD (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PPIF →	-1.056	-1.164	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MRPS2 →	-0.745	-1.152	<.001	<.001	3	5
BREAST	STX2 →	+1.133	+0.703	<.001	.008	3	4
BLOOD_Leukemia	EFHD2 →	-1.054	-0.984	.001	.006	2	5
BLOOD_Leukemia	RHOV →	-0.568	-1.005	.001	<.001	3	4
BLOOD_Leukemia	ESYT1 →	+0.953	+1.019	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902993 vs PPIF — LUNG_NSCLC_LUAD

Explore this scatter interactively →