Mitotic DNA replication

Across TCGA patient cohorts, RNA activity of the Mitotic DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, MYBL2, and E2F1, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication activity versus GINS1 in LIHC (Pearson r = 0.91).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	GINS1 →	+1.948	+0.096	<.001	<.001	3	33
LIHC	MYBL2 →	+2.767	+0.090	<.001	<.001	3	33
LIHC	E2F1 →	+2.216	+0.090	<.001	<.001	3	33
THYM	NCAPH →	+1.767	+0.088	<.001	<.001	3	33
ACC	ESPL1 →	+1.563	+0.074	<.001	<.001	3	33
BRCA	TICRR →	+1.211	+0.072	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902969 vs GINS1 — LIHC

Explore this scatter interactively →