Mitotic DNA replication

Across TCGA patient cohorts, RNA activity of the Mitotic DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM5, CENPI, and MCM4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication activity versus MCM5 in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM5 →	+1.026	+0.311	<.001	<.001	3	9
UCEC	CENPI →	+0.977	+0.382	<.001	<.001	3	9
BRCA	MCM4 →	+1.008	+0.739	<.001	<.001	3	9
GBM	ASF1B →	+1.112	+0.518	<.001	<.001	3	9
LSCC	EZH2 →	+0.785	+0.344	<.001	<.001	3	9
LSCC	RFC5 →	+0.682	+0.379	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902969 vs MCM5 — UCEC

Explore this scatter interactively →