Mitotic DNA replication

Across TCGA cell cohorts, RNA activity of the Mitotic DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM179B, KLF3, and RNF115, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM179B grouped by Mitotic DNA replication-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM179B →	+0.475	+0.180	.003	.001	3	5
BLOOD_Myeloma	KLF3 →	-2.882	-0.171	.001	.004	3	4
BLOOD_Lymphoma	RNF115 →	+0.950	+0.242	<.001	.006	2	5
BREAST	EME2 →	+1.700	+0.161	<.001	.001	3	4
BLOOD_Leukemia	GNPTG →	+0.821	+0.192	.001	<.001	3	4
BLOOD_Leukemia	PMFBP1 →	+0.608	+0.138	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM179B by Mitotic DNA replication activity — BLOOD_Leukemia

Explore this box plot interactively →