Mitotic DNA replication

Across TCGA cell cohorts, RNA activity of the Mitotic DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM6, LYAR, and RPA2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication activity versus MCM6 in SOFT_TISSUE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MCM6 →	+1.438	+0.417	.006	.005	3	9
LUNG_NSCLC_LUAD	LYAR →	+0.865	+0.244	.004	.007	3	7
SOFT_TISSUE	RPA2 →	+1.061	+0.398	.008	.005	3	7
LUNG_NSCLC_LUSC	MAD2L1 →	+1.032	+0.300	.001	.002	3	7
BLOOD_Myeloma	NCL →	+0.846	+0.095	<.001	<.001	3	6
LARGE_INTESTINE	PPAT →	+0.707	+0.277	.005	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902969 vs MCM6 — SOFT_TISSUE

Explore this scatter interactively →