Positive regulation of protein localization to early endosome

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein localization to early endosome pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MICAL3, PCYT1A_S323, and MICAL3_S1310, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to early endosome activity versus MICAL3 in GBM (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MICAL3 →	+0.388	+0.067	.001	.001	2	6
OV	PCYT1A_S323 →	-1.280	-0.076	<.001	<.001	3	5
BRCA	MICAL3_S1310 →	+0.561	+0.061	<.001	<.001	3	5
BRCA	NIPSNAP1 →	+0.306	+0.047	.006	<.001	3	5
OV	TNKS1BP1_S893 →	+0.502	+0.073	.005	<.001	3	4
PDAC	RABGAP1_S56 →	-0.461	-0.060	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902966 vs MICAL3 — GBM

Explore this scatter interactively →