Positive regulation of protein localization to early endosome

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to early endosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KBTBD8, LRRC14, and NPM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KBTBD8 grouped by Positive regulation of protein localization to early endosome-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KBTBD8 →	+1.038	+0.836	.007	.008	3	4
LIVER	LRRC14 →	-0.879	-1.178	.002	.003	3	4
STOMACH	NPM3 →	+1.158	+1.226	.008	.002	3	4
OESOPHAGUS	PDP2 →	+1.160	+1.215	.003	.004	3	4
KIDNEY	AASS →	+1.917	+1.162	<.001	.002	3	4
CNS	PKD1 →	+0.932	+1.087	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KBTBD8 by Positive regulation of protein localization to early endosome activity — BLOOD_Leukemia

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