Positive regulation of protein localization to early endosome

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to early endosome pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKN2, TLN1, and SPATA22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKN2 grouped by Positive regulation of protein localization to early endosome-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PKN2 →	+0.608	+0.264	.001	.006	3	6
LIVER	TLN1 →	+0.508	+0.168	.001	.006	3	5
LIVER	SPATA22 →	+0.166	+0.127	<.001	.004	3	5
BREAST	ZCCHC3 →	+0.205	+0.168	.001	<.001	3	5
LIVER	CCDC47 →	-0.155	-0.163	.009	.004	3	4
LIVER	SRSF2 →	-0.544	-0.175	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKN2 by Positive regulation of protein localization to early endosome activity — LIVER

Explore this box plot interactively →