"Regulation of mitochondrial electron transport, NADH to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Regulation of mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the CESC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC15, MIR210, and PINK1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mitochondrial electron transport, NADH to ubiquinone" activity versus DNAJC15 in CESC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	DNAJC15 →	+1.268	+0.067	<.001	<.001	3	27
DLBC	MIR210 →	-1.315	-0.078	<.001	<.001	3	23
PCPG	PINK1 →	+1.130	+0.073	<.001	<.001	3	20
ACC	KIF18A →	-1.194	-0.072	<.001	<.001	3	17
ACC	ILF3 →	-0.648	-0.061	<.001	<.001	3	17
DLBC	MYO19 →	-0.729	-0.065	.007	.003	1	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902956 vs DNAJC15 — CESC

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