"Regulation of mitochondrial electron transport, NADH to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Regulation of mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TAF7_S213, CTDSPL2, and GPATCH11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mitochondrial electron transport, NADH to ubiquinone" activity versus TAF7_S213 in LUAD (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TAF7_S213 →	-0.282	-0.049	.003	.006	3	4
LUAD	CTDSPL2 →	-0.198	-0.064	.001	<.001	3	4
GBM	GPATCH11 →	-0.349	-0.091	<.001	<.001	3	4
LUAD	KCTD12 →	-0.171	-0.048	.002	.007	3	4
PDAC	ARHGAP25_S512 →	-0.359	-0.059	.001	.002	3	4
LUAD	ARHGEF16 →	+0.416	+0.078	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902956 vs TAF7_S213 — LUAD

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