"Regulation of mitochondrial electron transport, NADH to ubiquinone"

Across TCGA patient cohorts, RNA activity of the "Regulation of mitochondrial electron transport, NADH to ubiquinone" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRX5, SGCA, and RPL31P16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of mitochondrial electron transport, NADH to ubiquinone" activity versus IRX5 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRX5 →	+0.917	+0.186	<.001	<.001	3	4
GBM	SGCA →	-0.787	-0.100	<.001	.001	3	3
GBM	RPL31P16 →	+0.129	+0.086	.005	.001	3	3
UCEC	NRADDP →	-0.339	-0.156	.008	.006	2	4
COAD	NUP50-DT →	+0.479	+0.118	.001	.001	3	3
COAD	FAM184B →	+0.138	+0.096	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902956 vs IRX5 — OV

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