Positive regulation of dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS1_S1393, AKAP12, and AKAP12_S612, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine maintenance activity versus TNS1_S1393 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS1_S1393 →	+0.746	+0.060	.001	<.001	3	7
BRCA	AKAP12 →	+0.684	+0.074	<.001	<.001	3	6
HNSC	AKAP12_S612 →	+0.735	+0.091	<.001	.003	3	6
BRCA	DCN →	+0.641	+0.064	.002	<.001	3	6
BRCA	KANK2 →	+0.600	+0.082	<.001	<.001	3	6
HNSC	NEDD9 →	+0.546	+0.122	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902952 vs TNS1_S1393 — BRCA

Explore this scatter interactively →