Positive regulation of dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOT2P2, CCDC138, and MYH7B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine maintenance activity versus GOT2P2 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GOT2P2 →	-0.225	-0.438	<.001	<.001	3	3
LSCC	CCDC138 →	+0.454	+0.728	.006	<.001	3	3
CCRCC	MYH7B →	+0.265	+0.426	.002	.007	3	3
LUAD	CLMP →	-0.563	-0.475	.003	.008	3	2
LUAD	NTM →	-0.628	-0.305	.001	.006	2	3
LUAD	LAYN →	-0.431	-0.337	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902952 vs GOT2P2 — LUAD

Explore this scatter interactively →