Positive regulation of dendritic spine maintenance

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine maintenance pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGRN, GPX2, and RNF7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGRN grouped by Positive regulation of dendritic spine maintenance-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AGRN →	-0.351	-0.215	.008	.007	3	4
UPPER_AERODIGESTIVE_TRACT	GPX2 →	+0.165	+0.165	.004	.002	3	4
SOFT_TISSUE	RNF7 →	+0.206	+0.484	.002	<.001	3	4
BLOOD_Lymphoma	ARHGAP29 →	+0.178	+0.204	<.001	.001	3	4
PANCREAS	ACTRT3 →	-0.183	-0.228	.001	<.001	3	3
BLOOD_Lymphoma	PLEKHG1 →	+0.355	+0.242	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGRN by Positive regulation of dendritic spine maintenance activity — BLOOD_Leukemia

Explore this box plot interactively →