Regulation of dendritic spine maintenance

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP31_S1432, CD36, and JCAD_S1044, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine maintenance activity versus ARHGAP31_S1432 in UCEC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP31_S1432 →	+0.925	+0.080	.002	.006	3	7
OV	CD36 →	+1.052	+0.047	.001	.001	3	6
BRCA	JCAD_S1044 →	+0.452	+0.040	<.001	<.001	3	6
PDAC	SEPTIN4_S117 →	+0.590	+0.054	<.001	<.001	3	6
BRCA	RSU1 →	+0.394	+0.076	<.001	<.001	3	6
BRCA	SERPING1 →	+0.566	+0.061	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902950 vs ARHGAP31_S1432 — UCEC

Explore this scatter interactively →