Regulation of dendritic spine maintenance

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic spine maintenance pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MKI67, LRTOMT, and SLC1A4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine maintenance activity versus MKI67 in OESOPHAGUS (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MKI67 →	+1.050	+0.272	.004	<.001	3	4
URINARY_TRACT	LRTOMT →	+0.962	+0.473	<.001	.002	3	4
BONE	SLC1A4 →	-2.504	-0.205	<.001	.007	3	4
BREAST	ZNF426 →	+1.068	+0.172	.007	.007	3	3
BREAST	C17orf100 →	+0.727	+0.193	.007	.003	3	3
BONE	EXOSC5 →	-0.849	-0.275	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902950 vs MKI67 — OESOPHAGUS

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