Protein localization to early endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to early endosome pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FUT8, CCNYL1, and ZNF112, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FUT8 grouped by Protein localization to early endosome-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FUT8 →	-1.747	-1.970	.001	<.001	3	4
LUNG_SCLC	CCNYL1 →	-1.091	-1.244	.004	.006	3	4
LIVER	ZNF112 →	+0.450	+1.200	.003	.005	2	5
CNS	PLD4 →	-0.213	-1.116	.005	<.001	3	4
BLOOD_Lymphoma	EXOC3L4 →	-0.590	-1.573	.009	.002	3	4
OESOPHAGUS	ZNF736 →	+1.570	+0.928	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FUT8 by Protein localization to early endosome activity — KIDNEY

Explore this box plot interactively →