Protein localization to early endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to early endosome pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS3, S100P, and F12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to early endosome activity versus RPS3 in CNS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RPS3 →	-0.699	-0.879	.003	.004	3	4
LUNG_NSCLC_LUAD	S100P →	-3.313	-0.652	.006	.009	3	4
SKIN	F12 →	-2.102	-1.884	.006	<.001	3	3
LUNG_NSCLC_LUAD	PLK2 →	+1.844	+0.974	.005	<.001	3	3
SKIN	KCTD2 →	+0.535	+1.384	.002	.002	3	3
SOFT_TISSUE	APH1B →	+1.081	+1.327	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902946 vs RPS3 — CNS

Explore this scatter interactively →