Positive regulation of alcohol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS10, F13A1, and ISM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alcohol biosynthetic process activity versus RPS10 in LUAD (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS10 →	-0.279	-0.346	.001	<.001	3	4
LUAD	F13A1 →	+0.987	+0.476	<.001	.001	2	4
CCRCC	ISM1 →	+0.704	+0.451	.003	.007	3	3
CCRCC	GTF3A →	+0.259	+0.460	.001	.003	3	3
CCRCC	PRKAB2 →	-0.374	-0.615	.001	.001	3	3
CCRCC	RAVER2 →	-0.340	-0.509	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902932 vs RPS10 — LUAD

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