Positive regulation of alcohol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of alcohol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX31, ANGPTL2, and DOCK8_S451, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of alcohol biosynthetic process activity versus DDX31 in BRCA (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DDX31 →	-0.252	-0.628	<.001	<.001	3	4
PDAC	ANGPTL2 →	+0.496	+0.620	<.001	<.001	3	3
OV	DOCK8_S451 →	+0.703	+0.687	<.001	<.001	3	3
OV	EPB41L2_S550 →	+0.688	+0.708	<.001	<.001	3	3
BRCA	KMT2A_S2391 →	-1.089	-1.294	<.001	<.001	3	3
GBM	RPRD2 →	-0.231	-0.533	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902932 vs DDX31 — BRCA

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