Negative regulation of alcohol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMZ1, CEND1, and CCZ1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMZ1 grouped by Negative regulation of alcohol biosynthetic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AMZ1 →	+0.324	+1.809	.005	.002	3	4
SOFT_TISSUE	CEND1 →	-2.635	-1.128	.002	.005	3	4
BONE	CCZ1B →	+0.685	+1.247	.006	.006	3	3
BLOOD_Leukemia	SLC37A3 →	+1.852	+1.244	.009	.008	2	4
OESOPHAGUS	SEC22B →	+1.116	+0.904	.001	.009	3	3
OESOPHAGUS	KIF3C →	+1.290	+0.978	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMZ1 by Negative regulation of alcohol biosynthetic process activity — BONE

Explore this box plot interactively →