Regulation of alcohol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of alcohol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEU1, ERLIN2, and LSM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of alcohol biosynthetic process activity versus NEU1 in KIDNEY (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NEU1 →	+1.448	+0.434	.005	.002	3	6
BREAST	ERLIN2 →	+1.761	+0.376	<.001	<.001	3	6
STOMACH	LSM1 →	+0.815	+0.224	.001	.003	2	6
UPPER_AERODIGESTIVE_TRACT	TMPRSS13 →	-1.910	-0.233	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	TMEM184A →	-1.952	-0.261	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	DUSP28 →	-1.011	-0.345	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902930 vs NEU1 — KIDNEY

Explore this scatter interactively →