Positive regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO4, TMEM267, and ZNF131, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein polyubiquitination activity versus FBXO4 in CHOL (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	FBXO4 →	+1.037	+0.053	.001	.006	2	31
UVM	TMEM267 →	+1.159	+0.046	<.001	<.001	3	30
UVM	ZNF131 →	+1.099	+0.048	<.001	<.001	3	30
UVM	FASTKD3 →	+1.048	+0.048	<.001	<.001	3	29
CHOL	C5orf34 →	+1.111	+0.051	<.001	.008	1	30
UVM	RAP2C →	+1.223	+0.051	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902916 vs FBXO4 — CHOL

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