Positive regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein polyubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT1_S532, STAT1, and TAPBP, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein polyubiquitination activity versus STAT1_S532 in PDAC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STAT1_S532 →	+0.995	+0.036	<.001	<.001	3	9
LUAD	STAT1 →	+0.604	+0.071	<.001	<.001	3	8
UCEC	TAPBP →	+0.561	+0.067	<.001	<.001	3	7
UCEC	CD40 →	+0.727	+0.069	.001	.008	3	7
LUAD	GBP1 →	+0.725	+0.062	<.001	<.001	3	7
COAD	PARP14 →	+0.305	+0.031	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902916 vs STAT1_S532 — PDAC

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