Positive regulation of protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX5, RAD52, and ASS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX5 grouped by Positive regulation of protein polyubiquitination-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PEX5 →	+0.597	+0.232	.005	.001	3	3
LUNG_SCLC	RAD52 →	+0.898	+0.282	.001	.006	3	3
STOMACH	ASS1 →	+4.286	+0.377	.004	.003	3	3
BLOOD_Myeloma	PRDM5 →	-2.685	-0.569	.003	.008	3	3
LUNG_SCLC	BTBD7 →	+0.877	+0.388	.004	<.001	2	4
LUNG_SCLC	MAP4K3 →	+0.813	+0.348	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX5 by Positive regulation of protein polyubiquitination activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →