Negative regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein polyubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DTX3L, PLAA, and DTX3L_S539, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein polyubiquitination activity versus DTX3L in OV (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DTX3L →	+0.579	+0.086	<.001	<.001	3	6
GBM	PLAA →	+0.508	+0.088	<.001	<.001	3	5
LUAD	DTX3L_S539 →	+0.602	+0.057	<.001	<.001	3	5
HNSC	XAF1 →	+0.413	+0.046	.002	.001	3	5
HNSC	MX1 →	+0.798	+0.054	.002	.003	3	5
LUAD	DNAJA1 →	+0.205	+0.058	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902915 vs DTX3L — OV

Explore this scatter interactively →