Negative regulation of protein polyubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein polyubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNASE1, CAV3, and MND1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein polyubiquitination activity versus DNASE1 in COAD (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DNASE1 →	-0.685	-0.302	<.001	.003	3	3
CCRCC	CAV3 →	-0.161	-0.325	<.001	.006	3	3
GBM	MND1 →	-0.387	-0.388	.009	.007	2	3
GBM	RNU6-359P →	+0.327	+0.359	<.001	.004	3	2
LSCC	PARP14 →	+0.447	+0.318	.007	.003	2	3
LSCC	KLRC4 →	+0.449	+0.430	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902915 vs DNASE1 — COAD

Explore this scatter interactively →