Negative regulation of protein polyubiquitination

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein polyubiquitination pathway is significantly associated with the drug response of multiple features, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Dasatinib, Trichostatin A, and Masitinib, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Dasatinib grouped by Negative regulation of protein polyubiquitination-low versus -high activity in OESOPHAGUS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Dasatinib →	+1.016	+0.291	.040	.045	3	4
KIDNEY	Trichostatin A →	+1.036	+0.094	.006	.005	3	3
OESOPHAGUS	Masitinib →	+0.496	+0.291	.015	.045	3	3
CNS	Staurosporine →	+0.926	+0.082	.004	.011	3	2
CNS	EphB4_9721 →	+0.859	+0.087	.025	.009	3	2
CNS	AZD8931 →	+0.826	+0.087	.037	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Dasatinib by Negative regulation of protein polyubiquitination activity — OESOPHAGUS

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