Negative regulation of supramolecular fiber organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of supramolecular fiber organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMTOR3, SLC35A2, and MED27, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMTOR3 grouped by Negative regulation of supramolecular fiber organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LAMTOR3 →	+0.601	+0.154	<.001	.001	3	5
BLOOD_Leukemia	SLC35A2 →	+0.471	+0.172	.009	.002	3	4
BLOOD_Leukemia	MED27 →	+0.829	+0.192	.002	<.001	3	4
URINARY_TRACT	BCR →	+1.251	+0.405	.002	<.001	3	4
LIVER	GAS6 →	-4.431	-0.299	<.001	.002	2	4
BLOOD_Lymphoma	ERCC1 →	-0.733	-0.222	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMTOR3 by Negative regulation of supramolecular fiber organization activity — BLOOD_Leukemia

Explore this box plot interactively →