Negative regulation of supramolecular fiber organization

Across TCGA cell cohorts, RNA activity of the Negative regulation of supramolecular fiber organization pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPE, STON2, and EIF4E2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of supramolecular fiber organization activity versus RPE in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPE →	+1.442	+0.352	.003	<.001	3	6
KIDNEY	STON2 →	-1.770	-0.327	<.001	.004	3	5
UPPER_AERODIGESTIVE_TRACT	EIF4E2 →	+0.765	+0.278	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ACTR2 →	+0.921	+0.271	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	METTL21A →	+1.032	+0.269	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	RAB7A →	+0.685	+0.232	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902904 vs RPE — UPPER_AERODIGESTIVE_TRACT

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