Negative regulation of autophagosome assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of autophagosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRP9, AKAP8_S328, and PDE3A_S312, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of autophagosome assembly activity versus SRP9 in COAD (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SRP9 →	-0.276	-0.034	.002	<.001	3	4
PDAC	AKAP8_S328 →	-0.513	-0.044	.006	<.001	3	4
CCRCC	PDE3A_S312 →	+0.533	+0.042	.002	.001	3	4
UCEC	CEP170_S881 →	+0.466	+0.054	<.001	<.001	3	4
BRCA	TOP1_S394 →	-0.448	-0.031	.007	.001	3	4
COAD	UTP15 →	-0.237	-0.029	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902902 vs SRP9 — COAD

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